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The New York Mets hope the return of Juan Soto finally gets them off their 12-game losing streak as they host the Minnesota Twins in the second game of their series on Wednesday night.
With New York getting reinforcements and Minnesota starting an untested pitcher, I like the home team to snap its skid in my Twins vs. Mets predictions.
Find out more in our free MLB picks for April 22.
Who will win Twins vs Mets today: Mets -1.5 (+140)
Juan Soto returns to the New York Mets lineup tonight, and he’s desperately needed.
The Mets have scored just 13 total runs over their last eight games heading into tonight’s contest, and bringing back Soto’s .355 batting average and .412 OBP is the spark they’re looking for.
New York will also benefit from Minnesota calling up left-hander Connor Prielipp for his MLB debut. Prielipp posted a 4.03 ERA across 82.2 innings of minor league action in 2025.
Meanwhile, Mets starter Clay Holmes sports a 1.96 ERA through four starts, and the righty should help New York pull away at Citi Field.
COVERS INTEL: Prielipp has struggled with control at the minor league level, allowing 3.5 walks per nine innings with a career WHIP of 1.379.Twins vs Mets Over/Under pick: Over 7.5 (-115)
The Mets’ offense showed vague signs of life last night when Francisco Lindor hit a three-run homer. Minnesota eventually pushed through runs as well, and even in a game where both starting pitchers were excellent, the total of 7.5 proved too low.
I expect a similar outcome tonight. The Twins are scoring 5.09 runs per game, and they’ll get into the New York bullpen, as Holmes is averaging only 5.8 innings per start.
As I noted above, I also expect the Mets to find success against Prielipp in his debut start. I’m taking the Over again in this game.
- ML/RL bets: 5-6, -1.31 units
- Over/Under bets: 4-5, -1.26 units
Twins vs Mets odds
- Moneyline: Twins +135 | Mets -160
- Run line: Twins +1.5 (-156) | Mets -1.5 (+140)
- Over/Under: Over 7.5 (-115) | Under 7.5 (-105)
Twins vs Mets trend
The Over is 8-2 in Minnesota’s last 10 games overall. Find more MLB betting trends for Twins vs. Mets.
How to watch Twins vs Mets and game info
| Location | Citi Field, Queens, NY |
| Date | Wednesday, April 22, 2026 |
| First pitch | 7:10 p.m. ET |
| TV | Twins.TV, SNY |
| Twins starting pitcher | Connor Prielipp (0-0, 0.00 ERA) |
| Mets starting pitcher | Clay Holmes (2-2, 1.96 ERA) |
Twins vs Mets latest injuries
Twins vs Mets weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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