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The season is on the line for the Boston Bruins when they face the Buffalo Sabres in Game 5 at the KeyBank Center on Tuesday, April 28.
My top Bruins vs. Sabres predictions and NHL picks are calling for Buffalo to come through on home ice and send Boston packing.
Bruins vs Sabres Game 5 prediction
Bruins vs Sabres best bet: Sabres moneyline (-155)
The gap in five-on-five play between the Buffalo Sabres and Boston Bruins at TD Garden the past two games has been astronomical, so I love the Sabres finishing the series off in Game 5.
Buffalo drove possession with a 61.9 Corsi For percentage and generated an eye-poping 68.4% of the expected goals when adjusted for score and venue at 5-on-5, and most importantly, the Sabres solved Bruins goalie Jeremy Swayman with six goals in Game 4.
Hats off to Boston for rallying to their Game 2 win after gifting away the series opener, but this has turned ugly for the Bruins with the Sabres outscoring them 9-2 over the past two games to take a commanding 3-1 lead back home to the KeyBank Center.
Bruins vs Sabres Game 5 same-game parlay
While the Buffalo moneyline is my preference as a standalone best bet, the puck line provides a nice odds boost for this same-game parlay.
Boston hasn’t had an answer for the Tage Thompson–Alex Tuch duo, and they’ve clicked with winger Peyton Krebs for a 55.8 CF% and 63.3 xGF% at 5-on-5 while combining for 10 points during the series.
Tuch has been particularly dangerous with 2.52 expected goals and five high-danger scoring chances, with Thompson just as effective with 1.94 ixG and five HDSC, and the Bruins have also allowed the second-most goals and expected goals per 60 minutes this postseason.
Bruins vs Sabres SGP
- Sabres -1.5
- Tage Thompson Over 0.5 points
- Alex Tuch Over 0.5 points
Bruins vs Sabres odds for Game 5
- Moneyline: Bruins +140 | Sabres -170
- Puck Line: Bruins +1.5 (-180) | Sabres -1.5 (+145)
- Over/Under: Over 5.5 (-125) | Under 5.5 (+105)
Bruins vs Sabres trend
The Buffalo Sabres have covered the puck line in seven of their last nine games (+7.00 Units / 48% ROI). Find more NHL betting trends for Bruins vs. Sabres.
How to watch Bruins vs Sabres Game 5
| Location | KeyBank Center, Buffalo, NY |
| Date | Tuesday, April 28, 2026 |
| Puck drop | 7:30 p.m. ET |
| TV | TNT, Sportsnet |
Bruins vs Sabres latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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