Lions vs Roughriders Prediction, Picks & Odds for CFL Week 2

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A heartbreaking loss in the West Final ended the BC Lions’ 2025 season on a sour note, but Nathan Rourke & Co. will look to get revenge in Regina on Saturday night.

My Lions vs. Roughriders predictions expect BC to do just that, especially with Saskatchewan losing a bevy of pieces in the offseason.

Read more in my CFL picks for Saturday, June 13.

Lions vs Roughriders prediction

Lions vs Roughriders best bet: Lions moneyline (+115)

The BC Lions were essentially one first down away from punching their ticket to the Grey Cup last fall, and with added continuity under Buck Pierce heading into 2026, they’re the team to beat in the West.

BC is my early-season Grey Cup pick to finish the job in November. Featuring reigning MOP quarterback Nathan Rourke and 2025 receiving yards leader Keon Hatcher, this team is loaded on offense and returns the majority of its talent after leading the CFL in points (31.1) and yards per game (431.3) last season.

While the Saskatchewan Roughriders are the defending Grey Cup champions, they lost several game-changers on the defensive side of the ball, especially up front, including defensive end Malik Carney and linebacker A.J. Allen departing in free agency.

Facing the league’s best offense, expect a highly motivated BC squad to settle the score at Mosaic Stadium, and I’d play this up to +100.

Lions vs Roughriders same-game parlay

The Over has cashed in the last five head-to-head matchups that came before October, and with sunny and clear conditions expected at Mosaic Stadium, a pass-heavy contest should be on tap, especially given the Lions’ elite aerial attack.

Last year’s West Final was set at an O/U of 52.5, and that was despite conditions dipping to around -7 by kickoff, with both teams ultimately recording more rushing attempts than passing.

Lions vs Roughriders SGP

  • Lions moneyline
  • Over 52.5

Lions vs Roughriders odds

  • Spread: Lions +2 (-115) | Roughriders -2 (-105)
  • Moneyline: Lions +115 | Roughriders -135
  • Over/Under: Over 52.5 (-110) | Under 52.5 (-110)

Lions vs Roughriders trend

BC is 8-2 ATS against Saskatchewan over its last 10 head-to-head matchups. 

How to watch Lions vs Roughriders and game info

Location Mosaic Stadium, Regina, SK
Date Saturday, June 13, 2026
Kick-off 7:00 p.m. ET
TV TSN

Lions vs Roughriders key injuries

Lions: Isiah Cage OL (Out), Nate Demontagnac WR (Out), Josh Donovan OL (Out), Jett Elad DB (Out), Mark McNamee K (Out), Andrew Peirson OL (Out), Garry Peters DB (Out). 
Roughriders: Darius Bell OL (Out), Dylan Djete WR (Out), Daniel Johnson OL (Out), Lake Korte-Moore DL (Out), Benoit Marion DL (Out), Ryder Varga LB (Out), Nick Wiebe LB (Out). 

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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