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The San Francisco Giants head to Petco Park for a three-game series with their NL West counterpart, the San Diego Padres.
Both squads could use a victory in Monday’s opener after the Yankees swept San Francisco and San Diego dropped two of three to the Tigers.
My Giants vs. Padres predictions and MLB picks on Monday, March 30, fancy outfieder Jung Hoo Lee’s chances of crossing the plate.
Giants vs Padres predictions
Giants vs Padres best bet: Jung Hoo Lee Over 0.5 runs (+105)
After failing to score a run in either of the first two games of the season, the San Francisco Giants made a change at the top of the order by installing Jung Hoo Lee as the leadoff man on Saturday.
He responded by scoring the team’s only run of the season, so it’s likely he stays atop the order. That’s a premium spot against Walker Buehler (5.39 xERA, 5.66 FIP), who struggled mightily against lefties (.300 BA, 1.79 WHIP).
Lee stands a good chance of getting on base, and the heart of the order behind him has two left-handed bats (Luis Arraez, Rafael Devers) poised to knock Buehler around and drive Lee home.
COVERS INTEL: Jung Hoo Lee was much better against righties (118 wRC+) than lefties (77). He seldom struck out (9.1%) against the latter, walking nearly as many times (40) as he struck out (41).Giants vs Padres same-game parlay (SGP)
It’s a good spot for both lineups to break out of mini-slumps from the opening series. Both lineups were better than league average against RHP a year ago and face beatable starting pitchers on Monday.
Devers demolished right-handed pitching (151 wRC+) a year ago and has the advantage over Buehler, who is trying to reinvent himself as a junkball pitcher and lost 2 mph from his fastball in spring.
Landen Roupp gets the nod for San Francisco. While his 3.80 ERA was encouraging, it’s not sustainable given his poor 1.45 WHIP. He walked 4.9 batters per nine innings in spring, so it’s still an issue.
Giants vs Padres SGP
- Jung Hoo Lee Over 0.5 runs
- Rafael Devers Over 0.5 RBI
- First five innings Over 4.5
Giants vs Padres home run pick: Willy Adames (+422)
Willy Adames has reached 30+ home runs in each of the last two seasons. In his age-30 season with a revamped batting stance, Adames can be projected to continue hitting for power and posting an ISO around .200.
A year ago, he had reverse splits with a 112 wRC+ and 20 HRs against righties and a 95 wRC+ and 10 HRs against lefties.
Buehler struggles to keep left-handed hitters off base, but right-handed hitters dole out the damage, tagging him for an absurd 2.10 HR/9.
- Best bets: 2-0, +2.57 units
- SGPs: 1-1, +2.26 units
- HR picks: 0-2, -2.0 units
Giants vs Padres odds
- Moneyline: San Francisco +100 | San Diego -120
- Run line: San Francisco -1.5 (+150) | San Diego +1.5 (-200)
- Over/Under: Over 8.5 | Under 8.5
Giants vs Padres trend
The Giants have gone Over the first-five total in 23 of their last 35 games dating back to last season. Find more MLB betting trends for Giants vs. Padres.
How to watch Giants vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Monday, March 30, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | FS1 |
| Giants starting pitcher | Landen Roupp (2025: 7-7, 3.80 ERA) |
| Padres starting pitcher | Walker Buehler (2025: 10-7, 4.93 ERA) |
Giants vs Padres latest injuries
Giants vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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